Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is another important API. It is used to treat high blood pressure and heart failure. This medication works by relaxing blood vessels, which improves blood flow and lowers blood pressure. The significance of lisinopril in managing cardiovascular health showcases how APIs can directly influence public health outcomes.
Once an API is developed, it undergoes rigorous testing to ensure its safety and efficacy. This includes preclinical studies, often conducted in vitro (in test tubes) and in vivo (in live organisms), followed by multiple phases of clinical trials with human subjects. Each phase aims to assess different aspects, such as dosage safety, effectiveness, and adverse effects. This stringency is crucial, as even small changes in the API's chemistry can significantly affect the drug's performance and safety profile.
example of active pharmaceutical ingredient
Isoflurane is a widely used inhalational anesthetic that has gained prominence in both human and veterinary medicine. As a halogenated ether, isoflurane offers several advantages, including a rapid onset and offset of action, making it suitable for various surgical procedures and outpatient surgeries.